Published: 2019-09-25

Comparison of safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough: a randomized open label phase IV clinical trial

Arijit Ghosh


Background: To compare safety and efficacy of dextromethorphan and levocloperastine in treatment of dry cough.

Methods: Patients fulfilling the selection criteria were randomized into two groups. Patients in group A were administered dextromethorphan cough lozenges (5 mg) thrice daily for 7 days. Patients in group B were administered syrup levocloperastine (20 mg/5 ml) 5 ml thrice daily for 7 days. Severity and frequency of cough, and Leicester Cough Questionnaire (LCQ) score were assessed at the end of day 7.

Results: Levocloperastine significantly decreased (p<0.5) severity and frequency of cough compared to dextromethorphan at day 7. Levocloperastine also significantly increased LCQ score compared to dextromethorphan at day 7.

Conclusions: Levocloperastine is significantly more effective compared to dextromethorphan in treatment of dry cough.



Levocloperastine, Dry cough, Dextromethorphan

Full Text:



Morice AH, Jakes AD, Faruqi S, Birring SS, McGarvey L, Canning B, et al. A worldwide survey of chronic cough: amanifestation of enhanced somatosensory response. Eur Respir J. 2014;44:1149-55.

Scotti L, Borzani M. Cloperastine fendizoate in the treatment of coughproducing diseases in pediatrics. Minerva Pediatr. 1988;40:283–6.

Satish K, Sholapuri D, Niranjane V, Garg S. Efficacy and safety of levocloperastine in the treatment of dry cough: a prospective observational Study. J Assoc Phys India. 2018;66:71-5.

Dicpinigaitis PV, Morice AH, Birring SS, McGarvey L, Smith JA, Canning BJ, et al. Antitussive Drugs—Past, Present, and Future. Pharmacol Rev. 2014;66:468–512.

Yousaf N, Lee KK, Jayaraman B, Pavord ID, Birring SS. The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute). Cough 2011;7:4-6.

Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific Quality of Life Questionnaire. J Clin Epidemiol. 1994;47:81–7.

Edwards IR, Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet. 2000;356:1255‑9.

Pore R, Biswas S, Das S. Prevailing Practices for the Management of Dry Cough in India: A Questionnaire Based Survey. J Assoc Phys India. 2016;64:48-54.

Morice AH, McGarvey L, Pavord I. Recommendations for the management of cough in adults. Thorax. 2006;61:i1-24.

Cass LJ, Frederik WS, Andosca JB. Quantitative comparison of dextromethorphan hydrobromide and codeine. Am J Med Sci. 1954;227:291–6.

Aliprandi P, Castelli C, Bernorio S, Dell’Abate E, Carrara M. Levocloperastine in the treatment of chronic non-productive cough: comparative efficacy versus standard antitussive agents. Drugs Exp Clin Res. 2004;30:133-41.