Published: 2019-12-24

Drug utilization study in medicine intensive care unit in tertiary care hospital

Siddharth Suryakant Athawale, Madhuri D. Kulkarni


Background: The medical intensive care unit (MICU) is a setting were patients who are critically ill are admitted and thus usually receive a large number of drugs of different pharmacological classes due to life threatening illnesses which may be fatal. The various drugs used in MICU and there clinical outcome was investigated in this study.

Methods: Patients admitted between January 2017 to June 2018 in Medicine ICU of GMC Aurangabad were included in this study.

Results: Total of 351 prescriptions was analyzed from the medicine intensive care unit. Out of 351 patients 243 (69.23%) were male, while 108 (30.77%) were female. The mean age of the patients admitted in MICU was 42.78±18.14 years. The most common type of patients admitted in MICU have the diagnosis of organophosphorous poisoning (25.36%), followed by cerebrovascular accident (15.95%), pneumonitis (10.26%), snake bite (7.12%), chronic kidney disease (5.98%), diabetic ketoacidosis (5.70%) and seizure disorder (3.42%). The most common drugs used were ranitidine (99.71%) and ondansetron (99.43%). Among antibiotics cephalosporins were most commonly used, ceftriaxone (39.03%), cefotaxim (40.46%), cefoperazone and sulbactum (24.22%). Other antibiotics most commonly used were metronidazole (61.25%), amoxicillin and potassium clavulanate (26.78%), piperacillin and tazobactum (11.68%), meropenem (11.40%).

Conclusions: In conclusion, we found that in MICU utilization rate of gastroprotective (ranitidine), antiemetic (ondansetron) and antibiotics (cephalosporins) was high. The present study provides valuable insight about the overall pattern of drugs used in medicine intensive care unit.


Drug utilization, Medicine intensive care unit, Antibiotics

Full Text:



Wade O. Drug utilization and therapeutic audit. Br J Clin Pharmacol. 1980;9:227-8.

Laporte J, Porta M, Capella D. Drug utilization studies: a tool for determining the effectiveness of drug use. Br J Clin Pharmacol. 1983;16(3):301-4.

World Health Organization G. Promoting rational use of medicines: core components. WHO Policy Perspect Med no5Document WHO/EDM. 2002: 1-6.

Shinde R, Kale A, Chube S, Sawant M. Drug utilization study in medical intensive care unit in a rural tertiary care teaching hospital in Maharashtra. Int J Med Sci Public Heal. 2017;6(4):1.

Smythe MA, Melendy SBJ. An exploratory analysis of medication utilization in a medical intensive care unit. Crit Care Med. 2003;21(9):1319-23.

Sharma N, Parakh R, Sharma D, Sharma P, Sharma PNS. A Drug utilization study in Critically Ill Patients in a Tertiary care Teaching Hospital in North India. Am J Pharmtech Res. 2014;4(1):780-9.

Kacha HV, Mundhava SG, Kubavat AR. Assessment of drug use pattern, their cost and safety in emergency department at a tertiary care teaching hospital, Rajkot. Int J Pharm Sci Res. 2018;9(4):1638-43.

Anand N, Nayak IMN, Advaitha MV, Thaikattil NJ, Kantanavar KA. Antimicrobial agents’ utilization and cost pattern in an Intensive Care Unit of a Teaching Hospital in South India. Indian J Crit Care Med. 2016;20(5):274-9.

Barot PA, Malhotra SD, Rana DA, Patel VJ. Drug utilization in emergency medicine department at a tertiary care teaching hospital: A prospective study. J basic Clin Pharm. 2013;4(4):78-81.

Gupta DR. Drug prescribing pattern in intensive care unit (ICU) in a tertiary care teaching hospital in central India. Int J Pharma Bio Sci. 2015;6(3):325-9.

Arathy R, Chacko J, Pillai S, Bhanu A, Raphael RJM. Drug utilisation in medical intensive care unit: a retrospective analysis from a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2016;5(4):1201-4.

Benjamin B, Kumar BS, Udaykumar P, Swamy VBN. Comparative Drug Utilization of Antimicrobial Agents in Medical and Respiratory Intensive Care Units of a Tertiary Care Teaching Hospital in South India. Indian J Pharm Pract. 2016;9(2):123-30.

Al-Zakwani I, Al-Thuhli M, Al-Hashim A. Drug utilization pattern in an intensive care unit at a tertiary care teaching hospital in Oman. Asian J Pharm Clin Res. 2017;10(2):194-7.

Paudel R, Palaian S. Clinical Profile And Drug Utilization Pattern In An Intensive Care Unit Of A Teaching Hospital In Western Nepal Clinical Profile And Drug Utilization Pattern In An Intensive Care U. Arch Pharm Pract. 2011;2(3):163-9.

Asad E. Patanwala AR. Antiemetic therapy for nausea and vomiting in the emergency department. J Emerg Med. 2010;39(3):330-6.

Mamatha V, Parashivamurthy BM. Study of drug utilization pattern in emergency medicine ward at a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2017;6(4):868-73.

Drupad HS. Prospective and observational study of antimicrobial drug utilization in medical intensive care unit in a tertiary care teaching hospital. Int J Pharmacol Res. 2016;6(01):13-7.

John LJ, Devi P, John J, Guido S. Drug utilization study of antimicrobial agents in medical intensive care unit of a tertuart care hospital. Asian J Pharm Clin Res. 2011;4(2):2-5.

Shankar PR, Partha P, Dubey AK, Mishra P DV. Intensive care unit drug utilization in a teaching hospital in Nepal. Kathmandu Univ Med J. 2005;3(10):130-7.

Biswal S, Mishra P, Malhotra S, Puri GD, Pandhi P. Drug utilization pattern in the intensive care unit of a tertiary care hospital. J Clin Pharmacol. 2006;46(8):945-51.