Published: 2019-12-24

Analysis of prescription pattern of anemia in pregnancy: an observational, cross-sectional study

Prasad R. Amrale, Sagar S. Ahire, Reshma M. Vairage


Background: Anemia is a major health problem that affects 25% to 50% of the population of the world and approximately 50% of pregnant women. This research on the use of prescription medicines in anemia during pregnancy remains critically important. Prescribing patterns of the drug in the pregnant women include age, trimester, gravid condition, US-FDA risk category, WHO core indicators.

Methods: A prospective, cross sectional observational multicentric study was conducted in outpatient and inpatient departments of Indira Gandhi Hospital and Civil Hospital in Nasik, for period of 6 months. Ethical approval was taken prior to study from Independent ethics committee. A total of 197 patients were enrolled in the study. Inform consent form was obtained from the patients. After studying them; statistical analysis were done and result and conclusion were drawn.

Results: Out of 197 women’s prescriptions, the average number of drug per prescription was 2.14. 27.28% drugs were prescribed there brand name and 72.72% by generic name. Iron, folic acid and calcium were prescribed to all pregnant women. The majority of the patients were prescribed category A and category C drugs. No patients were given category X drug.

Conclusions: Nearly all prescription showed a prescribing practice for writing prophylactic iron and folic acid therapy in all pregnant women. No women was prescribed category X drug. Most of the drug prescribed in generics and thus, prescription pattern of our study set a fine example of prescribing behaviour.


Prescription pattern, Anemia, Pregnant women, Trimester

Full Text:



Ahankari A, Leonardi-Bee J. Maternal hemoglobin and birth weight: systematic review and meta-analysis. Int J Med Sci Public Health. 2015;4(4).

Sukrat B, Wilasrusmee C, Siribumrungwong B, McEvoy M, Okascharoen C, Attia J, et al. Hemoglobin concentration and pregnancy outcomes: a systematic review and meta-analysis. BioMed Res Int. 2013;2013:769057.

Chang S-C, O’Brien KO, Nathanson MS, Mancini J, Witter FR. Hemoglobin concentrations influence birth outcomes in pregnant African-American adolescents. J Nutr. 2003;133(7):2348-55.

Kalaivani K. Prevalence and consequences of anaemia in pregnancy. Indian J Med Res. 2009;130(5):627-33.

Tan EK, Tan EL. Alterations in physiology and anatomy during pregnancy. Pract Res Clin Obstetr Gynaecol. 2013;27(6):791-802.

Akhtar M, Hassan I. Case report of severe anaemia during late pregnancy. Hindawi Publish Corp Case Reports Obstetr Gynecol. 2012:485452:3.

MoghaddamTabrizi F, Barjasteh S, maternal hemoglobin levels during pregnancy and their association with birth weight of neonates. Iranian J Pediatr Hematol Oncol. 2015;l5(4):212-7.

Campos O. Doppler echocardiography during pregnancy: physiological and abnormal findings. Echocardiography. 1996;13(2):135-46.

Tang YD, Katz SD. Anaemia in Chronic Heart Failure. Circulation. 2006;118:2454-61.

Bothwell TH. Iron requirements in pregnancy and strategies to meet them 1, 2, 3. Am J Clin Nutr. 2000;72(1):257-64.

Puolakka J, Janne O, Pakarinen A, Vihko R. Serum ferritin in the diagnosis of anaemia during pregnancy. Acta Obstet Gynecol Scand Suppl. 1980;95:57-63.

Scott JM, Weir DG. Role of folc acid /folate in pregnancy prevention is better than cure. Recent Adv Obst Gynaecol. 1998;20:1-20.

Sharma JB, Shankar M. Anemia in pregnancy. JIMSA. 2010;23(4):253-60.

Abhishilani GD, Sagili H, Reddy R. Intravenous iron sucrose and oral iron for the treatment of iron deficiency anaemia in pregnancy. J Clin Diagnos Res. 2014;8(5):4-7.

Briggs GG, Greeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk, 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2002.

Mitchell AA, Gilboa SM, Werler MM, Kelley KE, Louik C, Hernandez-Diaz S. Study T.B.D.P. Medication used during pregnancy, with particular focus on prescription drugs: 1976-2008. Am J Obstet Gynecol. 2011;205(1):51-8.

Splinter MY, Sagraves R. Prenatal use of medications by women giving birth at a university hospital. South Med J. 1997;90:498-502.

Adhikari A, Biswas S, Gupta RK. Drug use behaviour of pregnant women in rural India. J Pak Med Assoc. 2011;61(4):381-3.

Yadav S, Evangeline GS. Prescribing pattern of drug on pregnant woman attending a teaching hospital. Int J Pharmacol Therap. 2016;6(1):9-26.

Gawde SR, Bhide SS, Patel TC, Chauhan AR, Mayadeo NM, Sawardekar SB. Drug prescription pattern in pregnant women attending antenatal outpatient department of a tertiary care hospital. Br J Pharma Res. 2013;3(1):1-12.