Published: 2022-08-24

Kaposi's sarcoma in a different concept from HIV-AIDS: report of a case in a patient with Behçet's disease and immunomodulatory drugs

Diego Mendoza Contreras, Jose Maria Zepeda Torres, Grecia Jazmín García Gutiérrez, Félix Osuna Gutiérrez, Larissa Michelle Navarro Soberanes


Kaposi's sarcoma (KS) is a malignant vascular neoplasm that typically appears opportunistically in patients with acquired immunodeficiency syndrome (AIDS); it can also arise in organ transplanted subjects and exceptionally in carriers of autoimmune diseases, such as Behçet's disease. A 23-year-old man with Behçet's disease who debuts with clinically and histologically compatible dermatosis with KS. Conclusions. KS is not exclusive to HIV-AIDS, it also prevails in situations of primary or secondary immunocompromision that favor its appearance, as is the case of Behçet's Disease and its immunomodulatory therapy. 


Behçet's disease, Immunomodulatory drugs, Case report

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Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med. 2013;137(2):289-94.

James ND, Stewart JS. Kaposi's sarcoma and AIDS. Int J STD AIDS. 1991;2(2):91-6.

Louthrenoo W, Kasitanon N, Mahanuphab P, Bhoopat L, Thongprasert S. Kaposi's sarcoma in rheumatic diseases. Semin Arthritis Rheum. 2003;32(5):326-33.

Etemad SA, Dewan AK. Kaposi Sarcoma Updates. Dermatol Clin. 2019;37(4):505-17.

Dupin N. Update on oncogenesis and therapy for Kaposi sarcoma. Curr Opin Oncol. 2020;32(2):122-8.

Rappersberger K, Stingl G, Wolff K. Kaposi’s sarcoma. In: Freedberg IM, Sisen AZ, Wolff K et al. Fitzpatrick’s Dermatology in General Medicine, 5th ed. New York, McGrawHill. 1999;1195-204.

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM et al. Identification of herpes virus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266:1865-9.

Mariggiò G, Koch S, Schulz TF. Kaposi sarcoma herpesvirus pathogenesis. Philos Trans R Soc Lond B Biol Sci. 2017;372(1732):20160275.

Rady PL, Hodak E, Yen A, Memar O, Trattner A, Feinmesser M et al. Detection of human herpes virus-8 DNA in Kaposi’s sarcoma from iatrogenically immunosuppressed patients. J Am Acad Dermatol. 1998;38:429-37.

Wen KW, Damania B. Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis. Cancer Lett. 2010;289(2):140-50.

Mezalek ZT, Harmouche H, Attar NE, Serraj K, Aouni M, Adnaoui M, Maaouni A. Kaposi's sarcoma in association with Behcet's disease: case report and literature review. Semin Arthritis Rheum. 2007;36(5):328-31.